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TASK Quarterly

KEY FACTORS GOVERNING FIBRIL FORMATION OF PROTEINS: INSIGHTS FROM SIMULATIONS AND EXPERIMENTS

Abstract

Fibril formation of proteins and peptides is associated with a large group of major human diseases, including Alzheimer’s disease, prion disorders, amyotrophic lateral sclerosis, type 2 diabetes, etc. Therefore, understanding the key factors that govern this process is of paramount importance. The fibrillogenesis of polypeptide chains depends on their intrinsic properties as well as on the external conditions. In this mini-review we discuss the relationship between fibril formation kinetics and the sequence, aromaticity, hydrophobicity, charge and population of the so called fibril-prone conformation in a monomer state. The higher the population, the faster is the fibril elongation and this dependence may be described by a single exponential function. This observation opens up a new way to understand the fibrillogenesis of bio-molecules at the monomer level. We will also discuss the influence of the environment with focus on the recently observed dual effect of crowders on the aggregation rates of polypeptide chains.

Keywords:

fibril formation, binding free energy

Details

Issue
Vol. 18 No. 3 (2014)
Section
Review
Published
2014-09-30
DOI:
https://doi.org/10.17466/TQ2014/18.3/Y
Licencja:
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • NGUYEN TRUONG CO

    SBI Building Quang Trung Software City, Institute for Computational Science and Technology
  • MAN HOANG VIET

    Polish Academy of Sciences, Institute of Physics
  • PHAN MINH TRUONG

    SBI Building Quang Trung Software City, Institute for Computational Science and Technology
  • MAKSIM KOUZA

    University of Warsaw, Faculty of Chemistry
  • MAI SUAN LI

    Polish Academy of Sciences, Institute of Physics

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