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TASK Quarterly
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  3. Vol. 20 No. 4 (2016)
  4. MOLECULAR DYNAMICS AND STRUCTURAL COMPARISON APPROACH TO UNDERSTANDING THE ROLE OF KNOTS IN PROTEINS

MOLECULAR DYNAMICS AND STRUCTURAL COMPARISON APPROACH TO UNDERSTANDING THE ROLE OF KNOTS IN PROTEINS

Abstract

The role of knots in proteins is still unclear. In this short review, we summarize the current knowledge about structural and dynamical differences between knotted and unknotted proteins. We show how the topological difference helps to distinguish the physical properties, characterize the biological activity or identify the biological function of knotted proteins. This knowledge can be used to correctly annotate protein family members and to identify new members.

Keywords:

knotted proteins, methyltransferases, TrmD, Trm5, TrmJ, Trm7

Details

Issue
Vol. 20 No. 4 (2016)
Section
Research article
Published
2016-12-29
DOI:
https://doi.org/10.17466/tq2016/20.4/h
Licencja:
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • AGATA P. PERLINSKA

    University of Warsaw, Centre of New Technologies, Inter-Faculty Individual Studies in Mathematics and Natural Sciences

  • JOANNA M. MACNAR

    University of Warsaw, Centre of New Technologies, Inter-Faculty Individual Studies in Mathematics and Natural Sciences, Faculty of Chemistry

  • JOANNA I. SULKOWSKA

    University of Warsaw, Centre of New Technologies, Faculty of Chemistry

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